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Mallinger et al. [68] disclosed a novel series of 1H-indazole derivatives and the applying of physicochemical property analyses to productively reduce in vivo metabolic clearance, minimize transporter-mediated biliary elimination even though sustaining acceptable aqueous solubility. The final results indicated that compound 114 was a potent selecti

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Mallinger et al. [68] disclosed a novel series of 1H-indazole derivatives and the applying of physicochemical home analyses to productively reduce in vivo metabolic clearance, decrease transporter-mediated biliary elimination though keeping satisfactory aqueous solubility. The effects indicated that compound 114 was a strong selective, and orally b

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